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Paclitaxel resistance

WebNov 11, 2024 · Paclitaxel is a chemotherapeutic agent that acts as an inhibitor of cellular mitosis and has been widely used in the treatment of triple-negative breast cancer … WebAug 4, 2024 · Circular RNAs (circRNAs) and epithelial to mesenchymal transition (EMT) have been implicated in the development of human cancer and paclitaxel resistance. CircRNA circ_0007534 has been described as a key oncogenic circular RNA that is upregulated in a variety of cancer tissues. However, whether circ_0007534 causes EMT …

Paclitaxel (Conventional) - Drugs.com

WebApr 11, 2024 · BackgroundThere are a variety of treatment options for recurrent platinum-resistant ovarian cancer, and the optimal specific treatment still remains to be determined. Therefore, this Bayesian network meta-analysis was conducted to investigate the optimal treatment options for recurrent platinum-resistant ovarian cancer.MethodsPubmed, … WebPaclitaxel (PTX) is a first-line drug for late-stage non-small cell lung cancer (NSCLC) patients who do not benefit from targeted therapy or immunotherapy. However, patients invariably develop resistance to PTX upon prolonged treatments. Although diverse mechanisms leading to PTX resistance have bee … load testing bridges https://laboratoriobiologiko.com

New insight towards development of paclitaxel and docetaxel …

WebIntroduction. Breast cancer (BC) remains the most common type of cancer among women. 1 Paclitaxel (PTX), a type of chemotherapeutic drug taxanes, is an antineoplastic drug, which induces cell death by impacting microtubule stabilization. 2 PTX has been clinically approved and used for BC treatment and is effective against early and metastatic BC. 3 … WebNov 19, 2010 · The chemical name of paclitaxel is 5β, 20-epoxy-1,2α,4, 7β,10β,13α-hexahydroxytax-11-en-9-one4, 10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine. The chemical formula of paclitaxel is C47H51O14, with a molecular weight of 853.9. It is highly lipophilic, insoluble in water, and melts at 217°C. WebDec 21, 2024 · Warning. This medicine may lower the ability of the bone marrow to make blood cells that the body needs. If blood cell counts get very low, this can lead to … indiana house bill 1001

Frontiers Generation of Two Paclitaxel-Resistant High-Grade …

Category:Prior acquired resistance to paclitaxel relays diverse …

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Paclitaxel resistance

Paclitaxel-Resistant Cell Line - an overview - ScienceDirect

WebJul 6, 2024 · Paclitaxel remained active in patients who had developed resistance to platinum-containing therapy (defined as tumor progression while on, or tumor relapse … WebMar 25, 2024 · Paclitaxel is a first line chemotherapeutic agent for the patients with metastatic breast cancer. But inherited or acquired resistance to paclitaxel leads to …

Paclitaxel resistance

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WebIntroduction. Breast cancer (BC) remains the most common type of cancer among women. 1 Paclitaxel (PTX), a type of chemotherapeutic drug taxanes, is an antineoplastic drug, … WebPaclitaxel (PTX), a tubulin-binding agent, is widely used and has shown good efficacy in the initial period of treatment for non-small cell lung cancer (NSCLC). However, the relatively rapid acquisition of resistance to PTX treatments that is observed in virtually all cases significantly limits its …

WebNov 1, 2016 · To address this issue, we established paclitaxel-resistant sublines of the SK-BR-3 and MCF-7 breast cancer cell lines that are capable of long-term proliferation in … WebWe used GEO data to generate paclitaxel resistance in two basal-like TNBC cell lines (SUM149 and MDA-MB-468). Seventy-one common upregulated differentially expressed genes (DEGs) and 11 downregulated DEGs were found to be related to paclitaxel resistance. By constructing protein-protein interactions, 28 hub proteins with a degree …

Web58 rows · BMS-184476 is a novel taxane (methylthiomethyl ether of paclitaxel) active … WebOct 22, 2014 · Paclitaxel (Taxol) is a chemotherapy drug commonly used to treat solid cancers including breast tumors ( 18 ). This toxin targets microtubules to interfere with the mitotic spindle, resulting in cell cycle arrest and ultimately apoptosis.

WebAug 8, 2013 · To test whether paclitaxel -induced inflammatory responses protect cells from chemotherapy, we measured IC 50 of paclitaxel in TLR4 + MDA-MB-231 and TLR4-negative HCC1806 cells. As shown in Fig. 2A and B, TLR4 + MDA-MB-231 was 4-fold more resistant to paclitaxel as compared with HCC1806 (IC 50 of 12.5 vs.3.25 nmol/L; P = …

WebA TPGS-incorporating nanoemulsion of paclitaxel circumvents drug resistance in breast cancer. Int J Pharm. 2014;471(1–2):206–213. 38. Chen F, Wu J, Zheng C, et al. TPGS modified reduced bovine serum albumin nanoparticles as a lipophilic anticancer drug carrier for overcoming multidrug resistance. load testing for powerappsWebWe used GEO data to generate paclitaxel resistance in two basal-like TNBC cell lines (SUM149 and MDA-MB-468). Seventy-one common upregulated differentially expressed … indiana house arrest conditionsWebJan 1, 2024 · Mechanisms of paclitaxel resistance by cancer cells have yet to be fully elucidated. One of the recent reviews broadly described the paclitaxel resistance mechanism in cancer cell caused by MDR efflux transporters overexpression, altered expression of microtubule-associated proteins or microtubule alternation (Das et al., … indiana house bill 1004 summaryWebFeb 16, 2024 · In this work, we established paclitaxel-resistant cells (A549-T) from parental cell lines by step-dose selection in vitro. Using methylation chip analysis and transcriptome sequencing, 43,426 differentially methylated genes … load testing car batteryWebJan 13, 2024 · Background: Drug resistance is a major obstacle in chemotherapy for ovarian cancer, wherein the up regulation of drug-resistant genes plays an important … indiana house bill 1001 2022WebOct 21, 2024 · PTX resistance mechanisms are different and involve alterations in α- and β-tubulin, increased expression and activity of multidrug resistance (MDR) efflux transporters, overexpression of anti-apoptotic proteins, inhibition of apoptotic and tumor-suppressor proteins, and modulation of several cytokines, chemokines, and transcription factor … indiana house bill 1001 2023WebAug 14, 2014 · Paclitaxel is one of the most effective chemotherapy drugs for advanced cervical cancer. However, acquired resistance of paclitaxel represents a major barrier to successful anticancer treatment. indiana house bill 1004