WebJun 25, 2024 · Aggregation prediction algorithms developed from biophysical studies of amyloids identified an aggregation-nucleating subdomain (p53 residues 251–258) in the hydrophobic core of the p53 DBD... WebMar 17, 2024 · Aggregation of the RNA-binding protein, TDP-43, is the unifying hallmark of amyotrophic lateral sclerosis and frontotemporal dementia. TDP-43-related neurodegeneration involves multiple changes to normal physiological TDP-43, which undergoes nuclear depletion, cytoplasmic mislocalisation, post-translational modification, …
Aggregation Prediction with Protein Surface Analyzer Schrödinger
WebFeb 27, 2007 · AGGRESCAN is a web-based software for the prediction of aggregation-prone segments in protein sequences, the analysis of the effect of mutations on protein … WebMay 20, 2010 · Aggregation decreases protein activity and raises concerns about an immunological response. We have recently developed a method based on full antibody atomistic simulations to predict antibody... in huh md chicago
Enantioselective Degrader for Elimination of Extracellular Aggregation ...
WebOct 20, 2024 · Aggregation is usually probed by the increase in fluorescence of the dye thioflavin T (ThT) on binding to fibrils containing regular β-sheet structure. The curve shows the key kinetic parameters that can be obtained from a fit of the aggregation data to a simple sigmoidal function. WebApr 14, 2024 · Protein aggregation is a hallmark of multiple human pathologies. Autophagy selectively degrades protein aggregates via aggrephagy. How selectivity is achieved has been elusive. Here, we identify the chaperonin subunit CCT2 as an autophagy receptor regulating the clearance of aggregation-prone proteins in the cell and the mouse brain. WebMay 3, 2024 · Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in Caenorhabditis elegans Chaolie Huang, Sara Wagner-Valladolid, Amberley D Stephens, Raimund Jung, Chetan Poudel, Tessa Sinnige, Marie C Lechler, Nicole Schlörit, Meng Lu Romain F Laine, Claire H Michel, Michele … mlsc internship challenge login